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Predicting sarcopenia from functional measures among community-dwelling older adults. Age Dordr. Osteoporosis and sarcopenia in older age. Role of exercise on sarcopenia in the elderly. Eur J Phys Rehabil Med. Hickson M. Nutritional interventions in sarcopenia: a critical review. Proc Nutr Soc.

Effect of cysteine-rich whey protein immunocal R supplementation in combination with resistance training on muscle strength and lean body mass in non-frail elderly subjects: a randomized, double-blind controlled study.

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J Nutr Health Aging. Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial. Amino acid supplementation increases lean body mass, basal muscle protein synthesis, and insulin-like growth factor-I expression in older women. J Clin Endocrinol Metab.

L-Carnitine | What Is It? Benefits, Dosage & When To Take - MYPROTEIN™

Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects. Clin Pharmacokinet. Carnitine: a nutritional, biosynthetic, and functional perspective. Mol Aspects Med. Dietary L-carnitine suppresses mitochondrial branched-chain keto acid dehydrogenase activity and enhances protein accretion and carcass characteristics of swine.

J Anim Sci. Supplementation with l-carnitine downregulates genes of the ubiquitin proteasome system in the skeletal muscle and liver of piglets. Nutr Metab Lond. Intake of low-dose leucine-rich essential amino acids stimulates muscle anabolism equivalently to bolus whey protein in older women at rest and after exercise.

Am J Physiol Endocrinol Metab. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Stipanuk MH. Leucine and protein synthesis: mTOR and beyond. Nutr Rev. A review of creatine supplementation in age-related diseases: more than a supplement for athletes. Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr. Effects of acute creatine monohydrate supplementation on leucine kinetics and mixed-muscle protein synthesis.

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J Appl Physiol Med Sci Sports Exerc. Wutzke KD, Lorenz H. The effect of l-carnitine on fat oxidation, protein turnover, and body composition in slightly overweight subjects. Skeletal muscle microbiopsy: a validation study of a minimally invasive technique. Eur Respir J. Composite biomarkers for assessing Duchenne muscular dystrophy: an initial assessment. Pediatr Neurol.

Reliability and intensity of the six-minute walk test in healthy elderly subjects.

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Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling.


PLoS One. Physiological effects beyond the significant gain in muscle mass in sarcopenic elderly men: evidence from a randomized clinical trial using a protein-rich food. Clin Interv Aging. Nutrient-rich dairy proteins improve appendicular skeletal muscle mass and physical performance, and attenuate the loss of muscle strength in older men and women subjects: a single-blind randomized clinical trial. Effects of whey proteins and carbohydrates on the efficacy of resistance training in elderly people: double blind, randomised controlled trial. Eur J Clin Nutr.

Effect of physical exercise training on muscle strength and body composition, and their association with functional capacity and quality of life in patients with atrial fibrillation: a randomized controlled trial. J Rehabil Med.

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Age-dependent decrease of carnitine content in muscle of mice and humans. Biochem Biophys Res Commun. Nutritional recommendations for the management of sarcopenia. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. J Cachexia Sarcopenia Muscle. Raloxifene and body composition and muscle strength in postmenopausal women: a randomized, double-blind, placebo-controlled trial. Eur J Endocrinol. Six-week improvements in muscle mass and strength during androgen therapy in older men.

Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. Phillips SM. Nutritional supplements in support of resistance exercise to counter age-related sarcopenia. Adv Nutr. D'Antona G, Nisoli E. Interdiscip Top Gerontol. Trends Endocrinol Metab. Glucocorticoids attenuate the central sympathoexcitatory actions of insulin. J Neurophysiol.

Effect of dietary carnitine and chromium on weight loss and composition of obese dogs. J Animal Sci. Sandri M. Protein breakdown in muscle wasting: role of autophagy-lysosome and ubiquitin-proteasome. Atrogin-1, MuRF-1, and sarcopenia. Appl Physiol Nutr Metab. Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies.

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Eur J Nutr. Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr. Differential response of muscle phosphocreatine to creatine supplementation in young and old subjects. Acta Physiol Scand. Creatine supplementation during resistance training in older adults-a meta-analysis. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr. Does vitamin-D intake during resistance training improve the skeletal muscle hypertrophic and strength response in young and elderly men?

Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns. J Clin Epidemiol.